August 17, 2009

Stepping up safety

Published: UF Health Science Center Web site

Aired: Health in a Heartbeat Radio Series

By Melissa M. Thompson

Warmer weather is just around the corner. But before you fire up the barbecue, roast marshmallows around a crackling campfire or burn yard debris, consider some common precautions to help snuff out a serious childhood health risk.

The same warm-weather activities that create lasting childhood memories are some of the leading causes of pediatric foot and ankle burns in the southeastern United States.

In what is thought to be the largest such evaluation to date, University of Florida burn experts found that sixty-nine percent of one-hundred-fifty-five pediatric foot and ankle burns they reviewed were caused by children walking on hot ashes, coals and embers. Some injuries occurred a day or more after fires were thought to be extinguished. Most youngsters were barefoot or wearing footwear that didn’t fully cover their feet, such as sandals.

The findings were published in the Journal of Burn Care and Research. Two-thirds of the ash burns occurred after children came into contact with burning yard waste or garbage, nearly a third were caused by campfires and six percent involved a barbecue.

About half the total cases studied… which also included scald, flame or contact burns… were classified as second-degree burns. More than a third were third-degree burns, the most serious type.

Burns can be easily prevented by using common sense. Parental supervision and wearing closed footwear are key. But the best form of prevention? Step up safety by learning how to extinguish fires appropriately.

August 12, 2009

Breezin’ Hot List: Viva Las Vegas Wedding Reception

Published: July 2, 2009, Breezin’ Entertainment Blog

Goal: Publicize Tampa event entertainment agency’s services while providing creative information about wedding trends

By Melissa M. Thompson

Maybe you’ve always wanted to elope on a whim in Vegas but never followed through. Maybe you’re a sucker for all things kitschy and cool, finding yourself drawn to the grit and glamor of The Strip’s hey-day. Maybe you just want to have tons of fun at your wedding reception. Whatever your inspiration, a Viva Las Vegas themed wedding reception might be what you’re looking for.

From blackjack and roulette gaming tables to showgirls and impersonators, you can transform your celebration from something guests have seen before to something they’ll never forget.

Show Girls
Our entertainment coordinators can work with you to secure the Vegas-style acts you feel will make your night memorable: Show girls to greet guests, Elvis Impersonators shaking their hips to your favorite Vegas-style songs, Cirque du Soleil-like performers to mesmorize guests.

Carry the theme through wedding favors from custom dice to scrumptious decorated cookies. Make your tablescapes stand out and go the distance with eye-popping details.

Clockwise from Left: Dice boxed favors by Good Things wedding favors; Vegas style favor cookies by Beaucoup featured on FavorIdeas.com; Christian Louboutin heels; Red and Black tablescape by Real Simple’s Simply Stated Blog; Polka Dot Wedding Cake by Cheesecake and Crime


Vegas Inspiration



October 1, 2008

Coming to America

UF occupational therapy professor Sherrilene Classen became an American citizen in May, 15 years after moving to the U.S. from her native South Africa.

UF occupational therapy professor Sherrilene Classen became an American citizen in May, 15 years after moving to the U.S. from her native South Africa.

Link to article: http://news.health.ufl.edu/Post/ThePost9_2008.pdf (see page 23)

Published: September 2008, The Post, University of Florida

By Melissa M. Thompson

UF assistant professor earns her stars and stripes after 15 years

Driving on the wrong side of the road — or learning to drive an American car, in five days, period — was hard enough to get used to, but then Sherrilene Classen, Ph. D., M.P.H., O.T.R., learned the truth about Smarties candies. They weren’t chocolate.

Three months after arriving in the United States, Classen, a native of South Africa, confessed to a friend she was craving the sweet treat. Expecting to find the familiar M&M-like candy sold in her home country, Classen almost gagged when the pastel spheres of pure sugar assaulted her tastebuds.

“My American friend got very excited, telling me that she could find (Smarties) for me right away,” said Classen, an assistant professor of occupational therapy in the UF College of Public Health and Health Professions who was recruited to practice occupational therapy in the U.S. in 1993.

“She presented me with these nasty little clumps of sugar. They were totally awful.”

Fifteen years later, Classen has adjusted to life in the country she now calls home and was sworn in as a U.S. citizen during a ceremony in May. But the road to American life wasn’t as sweet as it seems.

Classen was born in Bloemfontein, the capital of South Africa’s Free State province, where she learned to care for herself at a young age. Her father died when she was 6, forcing her mother to work three jobs and leaving Classen to raise her brother and sister.

“I remember talking about (my siblings) as ‘the children’ even though my brother is only a year younger than me and my sister five years,” she said. “That was my normal I never look back at it as a bad thing, instead I have learned life lessons such as you never get deterred, and you never give up.”

At 14, she was hired as a hairdresser’s weekend receptionist. She hasn’t stopped working since, financing her way through college at the University of the Orange Free State, where she earned a bachelor’s degree in occupational therapy. While working as an occupational therapist in South Africa, she received shiny pamphlets adorned with American flags and promising opportunity, education and security. This was enough to lure Classen away from her family and friends in search of a better, more adventurous life.

Today, Classen is excited to participate in activities many Americans take for granted — such as voting in the 2008 presidential election. As she thinks about casting her vote for the first time in November, she can’t help but remember her family in South Africa, where violence and crime are tearing communities apart.

“Few are excited about life in South Africa or hopeful about the country’s future,” she said. “But here, the stuff that excites me is just normal stuff for Americans. How powerful is it to read the Declaration of Independence and really understand those words? Life, liberty and the pursuit of happiness. In many developing countries, including South Africa, those are just empty words or wishful thinking.”

October 1, 2008

Science’s next generation

Naa Sika Williams, a UF senior majoring in exercise physiology, was one of several premed and graduate-school bound students from across the country to participate in UF National Institute of Health Summer Research Program this year. She and other students in the program spent their summers in labs like these doing research.

Naa Sika Williams, a UF senior majoring in exercise physiology, was one of several premed and graduate-school bound students from across the country to participate in UF National Institute of Health Summer Research Program this year. She and other students in the program spent their summers in labs like these doing research.

Link to article: http://news.health.ufl.edu/Post/ThePost9_2008.pdf

Published: September 2008, The Post, University of Florida Health Science Center

By Melissa M. Thompson

UF program gives undergrads research experience

When most 12-year-olds were doing their homework or playing pickup games of basketball with their friends, Dennis McLeod was in a lab surrounded by white coats and microscopes.

With a nudge from his mother, McLeod participated in research opportunities annually and today boasts a rich resume with experience in labs across the United States and Canada. Now 23, McLeod, who graduated in May with degrees in biology and Spanish from Morehouse College in Atlanta, is proof that early exposure to science can mold a child’s career path. But he said he knows there are kids who are not so lucky.

“I think we need more programs only geared toward students with zero research experience,” he said. “I can give you a list of 100 kids today who can’t get that experience.”

Researchers at the UF College of Medicine are trying to change that. This summer, McLeod and more than a dozen premedical and graduate school-bound students from universities across the country participated in UF’s National Institutes of Health Summer Research Program, a program aimed primarily at undergraduate minority students who are interested in medical research.

“The short-term goal of the program is to introduce bright young students to the world of medical research,” said Charles E. Wood, Ph.D., a professor and chair of the department of physiology and functional genomics in the College of Medicine and principal investigator of the NIH training grant that funds the program. “It is our hope that those students who are successful will become future academicians and help to solve the most pressing problems for which we now have no solution.”

Students are assigned faculty mentors who take them to their labs and assign research projects throughout the eight-week program. At the end of the program, participants present their findings to professors and their peers.

For Naa Sika Williams, a UF exercise physiology senior, the experience taught her the value of trial and error in the scientific process. She worked on a project involving antibodies and antigens and how they relate to cancer cells in mice.

The project provided an early lesson in the ups and downs of discovery. During her first attempt at culturing cells, the cells died.

“They just told me not to worry just to learn from my mistakes and move on,” she said.

The main benefit of the research boot camp is to help students stay competitive and on par with their peers in the medical and graduate school admissions process.

“When you read (research) in biology books it’s not the same as seeing it done and how much work goes into it,” Williams said. “If this program wasn’t here, I probably wouldn’t have done research. There are still students out there who will not have done research before they apply (to medical school).”

August 20, 2008

Obesity risk linked to history of chronic ear infections

ear

Link to release: http://news.ufl.edu/2008/08/14/ear-infection/

Published: Aug. 14, 2008, University of Florida and Health Science Center Web sites

Press generated: Calgary Herald (Canada), Vancouver Sun (Canada), Medical News Today, Middleton Journal (Ohio), Daily Advance (North Carolina), Austin American Statesman (Texas), Gainesville Sun, KTBS-TV ABC 3 Shreveport (LA)

By Melissa M. Thompson

GAINESVILLE, Fla. — More than 5 million children cope with the agonizing ache of ear infection annually, but a new discovery suggests damage to taste nerves caused by the common childhood ailment might increase the risk of obesity later in life, say University of Florida College of Dentistry researchers.

Chronic ear infections appear to trigger a preference for high-calorie food, leading to increased consumption and excessive weight gain in adulthood, said Linda Bartoshuk, a UF expert on the sense of taste and genetic variations in taste perception. She reported study findings from health surveys establishing the link at today’s (Aug. 14) annual meeting of the American Psychological Association in Boston.

Bartoshuk’s preliminary study findings suggested a link between the infections and obesity. Researchers from other academic institutions confirmed the discovery with data from three independent studies.

“We have known for a long time that ear infections can damage taste because the major taste nerve, the chorda tympani nerve, passes through the middle ear on its way to the brain,” said Bartoshuk, a presidential endowed professor of community dentistry and behavioral science affiliated with the McKnight Brain Institute’s Center for Smell and Taste. “When we learned that taste damage can intensify non-taste sensations from foods, all of the pieces of the puzzle fell into place.”

When ear infection pathogens damage the main sensory taste nerve it can intensify sensations produced by fatty foods. This heightens the preference for those foods and can lead to weight gain, Bartoshuk said.

In 1993, Bartoshuk and her students began collecting general health information from written questionnaires distributed during taste lectures she gave across the country. Since 1993, she has surveyed more than 6,500 people ages 16 to 92. With age, those individuals who had moderate to severe histories of ear infections gained weight at a faster rate than those who had never had an ear infection. Of respondents over 30 years old, 39 percent of those with no history of chronic ear infections were overweight or obese, whereas 51 percent of those with ear infections were overweight or obese.

In addition, UF researchers found that those with ear infections liked sweet foods such as cookies and milk chocolate 14 percent more than those without ear infections. And they liked high-fat foods such as mayonnaise and butter 18 percent more than those without ear infections.

In a supporting study examining the predictors of obesity in Puerto Rican children, obese children were more likely to have experienced ear infections.

“One public health consequence of these observations may well be to alert parents and pediatricians to the long-term consequences of childhood earaches,” said Jim Weiffenbach, a retired researcher from the National Institute of Dental and Craniofacial Research. “Knowledge of a sensory basis for this class of over-nutrition might allow for the development of new obesity prevention strategies.”

UF researchers and National Institutes of Health researchers are now examining whether tonsillectomies also influence weight gain. They suspect the procedure can damage other taste nerves, which might affect weight in a similar manner.

“Obesity is heavily inherited,” Bartoshuk said. “But (ear infections) are not genetic. This is environmental and this is something you can stop.”

August 20, 2008

Researchers find cancer-inhibiting compounds under the sea

hendrik

Hendrik Luesch, Ph.D.

Link to release: http://news.ufl.edu/2008/08/07/marine/

Published: Aug. 07, 2008, University of Florida Web site and Health Science Center Web site

Press generated: St. Petersburg Times, Tampabay.com, WUFT Gainesville, Gainesville Sun, Science Daily (Natl), Therapeutics Daily, Environmental News Network, Yahoo! India

By Melissa M. Thompson

GAINESVILLE, Fla. — University of Florida College of Pharmacy researchers have discovered a marine compound off the coast of Key Largo that inhibits cancer cell growth in laboratory tests, a finding they hope will fuel the development of new drugs to better battle the disease.

The UF-patented compound, largazole, is derived from cyanobacteria that grow on coral reefs. Researchers, who described results from early studies today (Aug. 7) at an international natural products scientific meeting in Athens, Greece, say it is one of the most promising they’ve found since the college’s marine natural products laboratory was established three years ago.

An initial set of papers in the Journal of the American Chemical Society also has garnered the attention of other scientists, and the lab is racing to complete additional research. The molecule’s natural chemical structure and ability to inhibit cancer cell growth were first described in the journal in February and the laboratory synthesis and description of the molecular basis for its anticancer activity appeared July 2.

“It’s exciting because we’ve found a compound in nature that may one day surpass a currently marketed drug or could become the structural template for rationally designed drugs with improved selectivity,” said Hendrik Luesch, an assistant professor in UF’s department of medicinal chemistry and the study’s principal investigator.

Largazole, discovered and named by Luesch for its Florida location and structural features, seeks out a family of enzymes called histone deacetylase, or HDAC.  Overactivity of certain HDACs has been associated with several cancers such as prostate and colon tumors, and inhibiting HDACs can activate tumor-suppressor genes that have been silenced in these cancers.

Although scientists have been probing the depths of the ocean for marine products since the early 1960s, many pharmaceutical companies lost interest before researchers could deliver useful compounds because natural products were considered too costly and time-consuming to research and develop.

Many common medications, from pain relievers to cholesterol-reducing statins, stem from natural products that grow on the earth, but there is literally an ocean of compounds yet to be discovered in our seas. Only 14 marine natural products developed are in clinical trials today, Luesch said, and one drug recently approved in Europe is the first-ever marine-derived anticancer agent.

“Marine study is in its infancy,” said William Fenical, a distinguished professor of oceanography and pharmaceutical sciences at the University of California, San Diego. “The ocean is a genetically distinct environment and the single, most diverse source of new molecules to be discovered.”

The history of pharmacy traces its roots back thousands of years to plants growing on Earth’s continents, used by ancient civilizations for medicinal purposes, Fenical added. Yet only in the past 30 years have scientists begun to explore the organisms in Earth’s oceans, he said. Fewer than 30 labs exist worldwide, and research dollars have only become available in the past 15 years.

HDACs are already targeted by a drug approved for cutaneous T-cell lymphoma manufactured by the global pharmaceutical company Merck & Co. Inc. However, UF’s compound does not inhibit all HDACs equally, meaning a largazole-based drug might result in improved therapies and fewer side effects, Luesch said.

Since 2006, Luesch and his team of researchers have screened cyanobacteria provided by collaborator Valerie Paul, head scientist at the Smithsonian Marine Station in Fort Pierce. They check the samples for toxic activity against cancer cells and last year encountered one exceptionally potent extract — the one that ultimately yielded largazole.

To conduct further biological testing on the compound, Luesch and his team have been collaborating with Jiyong Hong, an assistant professor in the department of chemistry at Duke University, to replicate its natural structure and its actions in the laboratory.

Luesch said that within the next few months he plans to study whether largazole reduces or prevents tumor growth in mice.

Luesch has several other antitumor natural products from Atlantic and Pacific cyanobacteria in the pipeline.

“We have only scratched the surface of the chemical diversity in the ocean,” Luesch said. “The opportunities for marine drug discovery are spectacular.”

July 29, 2008

Into the sunset

Link to article: http://news.health.ufl.edu/Post/ThePost_JULY08.pdf (SEE PAGE 23)

Published: July 2008, The POST, University of Florida Health Science Center

By Melissa M. Thompson

photo by Sarah Kiewel

photo by Sarah Kiewel

Longtime administrator Jerry Kidney retires

It’s the middle of May and Jerry Kidney is so close to retirement he can almost smell it. But instead of dreaming about the brisk air surrounding his 20-acre surrogate home in Maine, Kidney’s thoughts are focused solely on his son.

His adopted son Greg, an Army corporal, was wounded when a terrorist’s bomb exploded near his Humvee in Baghdad. Just two weeks away from his June retirement, Kidney’s office phone rings with updates from his wife and the hospital in Texas, where his son is recovering.

“We all look forward to retirement as a time to set aside usual responsibilities and pursue new experiences,” said Kidney, who has since retired as assistant vice president for health affairs for administrative support. “But sometimes reality sets in and through no act of our own, priorities get reset. We are thankful that Greg is alive, that he did not receive worse injuries … but that’s little consolation to the family of Greg’s buddy who lost his life in the explosion.”

Even as the father of six grapples with life’s speed bumps, he’s forced to find time to prepare for the retiree lifestyle. And it shows.

Among collections of cardboard boxes and half-eaten, orange-and-blue candy gifts remain nearly a dozen framed photographs of his ever-expanding brood that will no doubt be fixtures in his office until he officially moves out.

But for now, the family photos remind him of his New England roots, and his journey to the South. Born and raised in Maine, Kidney was accustomed to small-town life. He was valedictorian of his graduating class of 72 students. After graduating from college, he taught high school math and later moved to a job in higher education to provide for his growing family. In 1982, the man who admits he had never been south of Boston before he was 24 decided to interview for a job at UF, where he has been ever since.

“I’ll miss the good people I see around here every day,” he said. “But I’m so looking forward to (retirement). I love change. I think after we come back from Maine, it won’t be long before I look for something that gets me up in the morning.”

Well-known for his good nature and large family (he proudly announces he will be the grandfather of eight by Christmas), Kidney said all he wanted to do was retire without fuss or fanfare while riding quietly off into the sunset. But for someone who touched so many lives at UF and in the Gainesville community, it was difficult for Kidney to make a quiet exit.

“Jerry is going to be someone who takes so much institutional knowledge with him that he’s going to be hard to replace,” said Tom Harris, associate vice president for health affairs and Kidney’s longtime
lunch buddy. “He’ll do anything to help anybody and he never says, ‘It’s not in my job description.’ ”

Farewell festivities included a reception attended by four generations of Kidney’s family as well as friends and colleagues who gathered to reminisce. A hallway display pays tribute to the man of many talents with a montage of newspaper clippings and photographs. There’s Kidney riding his cherry-red Honda motorcycle. Acting in the Gainesville Community Playhouse’s production of “Guys and Dolls.” Volunteering at the Ronald McDonald House. He does it all.

Kidney said he will remain active in the community because his family will stay in Gainesville for nine months of each year and travel to scenic Maine during the summer. It might be beautiful there, but he’s not looking forward to footing the fuel bill.

“I bought a humongous fifth wheel (camper), and we’ll haul it up there and stay for the summer,” he said. “Down in the cafeteria, they have shrimp that’s 50 cents a piece. I fi gure it will cost me one shrimp per mile all the way up to Maine.”

June 26, 2008

Unmasking Gonzo

Link to article: http://www.jou.ufl.edu/pubs/communigator/index.php?id=67

Published: May 2008, communigator, UF College of Journalism and Communications Alumni Magazine

By Melissa M. Thompson

McKeen’s Thompson Tome Due out in July

It seemed fitting to pay tribute to the Kentucky-born journalist who lived life fast and hard by pouring two fingers of his favorite bourbon: Wild Turkey.

William McKeen (photo by Jason Henry)

William McKeen (photo by Jason Henry)

Department of Journalism Chair William McKeen sat in his living room in the middle of the night on Feb. 20, 2005, sipping the fiery liquor and remembering a writer whose razor-sharp prose enchanted and perplexed the masses, a hypnotic figure whose legend and provocative journalism even today inspires young-gun reporters.

At 11:15 p.m., Los Angeles Times Staff Writer Geoff Boucher, JM 2007, called McKeen with news of Hunter S. Thompson’s self-inflicted, fatal gunshot to the head and questions about the life of the man known as the gonzo journalist.

McKeen informed his wife, Nicole Cisneros, JM 2005. “She urged me to say a prayer for him,” he said.

Whether he’s asked to discuss the eccentric writer’s psyche and work or his complicated public and private relationships, McKeen is considered a Thompson expert by journalists and academics alike. All it takes is a glance around his office to see why. A wall stacked with hundreds of books showcases his penchant for rock ‘n’ roll and literary journalism titans like Tom Wolfe.

Among the mass of books are McKeen’s published projects, including his 1991 Hunter S. Thompson, an examination of Thompson’s work. Personal notes from Thompson, displaying his frantic penmanship, and black-and-white photographs of Thompson’s visit to Western Kentucky University, where McKeen taught in the late 1970s, document the journalists’ quirky acquaintance.

A framed, handwritten note scribbled in black marker hangs on a wall just below one from Tom Wolfe. The Thompson note reads: “I warned you about writing that vicious trash about me. Now you better get fitted for that black eye patch just in case one of yours gets gouged out by a bushy-haired stranger in a dimly lit parking lot. How fast can you learn Braille? You are scum.”

It’s signed “HST.”

“It was his way of letting me know he really liked the book,” McKeen said.

The framed portion of the note is an excerpt from an eight-foot scroll Thompson sent McKeen about a bull-sperm auction.

The birth of Outlaw

In the days following Thompson’s death, news outlets such as the St. Petersburg Times and CNN sought insight into Thompson’s life and work.

They called McKeen.

“When the person from People magazine called, I asked, ‘Well, aren’t you also going to talk to this person and that person?’ And she said, ‘No, we’re talking to you and Johnny Depp, and that’s it,’ ” McKeen recalled.

After a flurry of interviews, Cisneros suggested her husband’s next book should be a biography of Thompson. Outlaw Journalist: The Life and Times of Hunter S. Thompson was born.

“He’ll say all of his best ideas come from me, and it’s true,” she said, smiling.

Before Thompson died, McKeen entertained the idea of revising his first book about the journalist, but never seriously considered writing more about him. After a handful of Thompson books appeared in the early 1990s, he saw little demand for another biography.

Then Thompson died, and he felt the urge to write a book objectively examining the late journalist’s life – something he felt was lacking in the commercial market.

“The people who wrote those earlier books put themselves in it too much,” McKeen said. “I thought, you really need somebody who’s going to stand back and be objective and not a) try to show off – they try to write like Hunter Thompson and therefore look like fools – and b) they want to emphasize their role in the story. I thought I didn’t know him well enough to do that, but I did know him well enough to know what the real guy was like.”

McKeen, the author of five books and the editor of three, called his agent, Jane Dystel of Dystel and Goderich Literary Management. Dystel shopped McKeen’s idea around to publishers and landed a deal with a familiar editor at a familiar publishing company: Amy Cherry, vice president of communications and senior editor at W.W. Norton & Company, an independent publishing firm in New York City.

Cherry, who has worked at W.W. Norton for 23 years and with McKeen for nearly a decade, edited his last three books, including Rock and Roll is Here to Stay and Highway 61.

Originally, she wanted McKeen to write the biography as an oral history, but he fought for a narrative and won.

He started the book with a recreation of Thompson’s suicide using cell-phone records, but Cherry didn’t like it. She suggested telling the events in chronological order, he recalled. “She said, ‘Don’t mess with it. Just start at the beginning,’ ”

Typically, McKeen sends Cherry two to three chapters at a time. One of the greatest challenges in editing Outlaw, she said, was turning the seemingly endless supply of events in Thompson’s life into a cohesive chronology.

“Especially in writing biographies, it’s hard to keep everything straight,” Cherry said. “Occasionally, I would have to say to him, ‘You know, maybe this should go over here or what happened between these two events?’ ”

The manuscript, which is nearly 500 pages and about five inches thick, is scheduled for release on July 7. Cherry calls the book McKeen’s best writing to date.

“It’s the most mature work he has done,” she said. “Highway 61 was good, fun and engaging. But I think the depth he brought to this book was much stronger. He let you see, without psycho-analyzing, what Hunter S. Thompson thought and why he did what he did.”

The Gonzo effect

McKeen first became fascinated with Thompson’s work when he read “The Battle of Aspen,” an egomaniacal essay about the rise of hippie political power in Aspen, Colo., in 1970.

“There was a picture of him in the article where he had his head shaved,” McKeen said. “It was demonic. He looked like an alien. I thought, ‘This is a weird guy.’ ”

That image stayed with him. During the 1972 presidential elections, McKeen worked for a small newspaper in Bloomington, Ind., and read Thompson’s coverage of the campaign each week in Rolling Stone magazine.

He viewed the writing as a brilliant flight of fancy.

“There I was, a young reporter,” McKeen said, “and here was a guy who was so funny and so entertaining. I was attracted to it immediately.”

McKeen, 19 at the time, tried to emulate Thompson’s style on an assignment in Roselawn, Ind., while covering the Mr. and Ms. Nude America pageant at a now defunct nudist resort, Naked City. The result: an article riddled with incomplete sentences, unworthy of being published.

“The lesson I learned is that only one person can write like Hunter S. Thompson,” he said, “and that’s Hunter S. Thompson.”

In 1978, McKeen met and interviewed Thompson when he started his teaching career at Western Kentucky. At the time, he was hosting a speaking engagement featuring the writer. He was surprised. Backstage, Thompson was a Southern-bred gentleman who hated to say no to enthusiastic fans, especially women.

“He was not at all what I expected,” McKeen said. “He was kind and gentlemanly. People would come up to him and say, ‘Hunter, I met you eight years ago in Atlanta.’ He would always pretend to remember. He didn’t want to hurt anyone’s feelings.”

Once Thompson stepped onto the stage, he transformed into character. He became the straight-shooting wild man of infamy. He changed the way he walked, amped up his language and exaggerated his motions so that he was like a cartoon character.

“His public persona was a literary creation as much as Huck Finn or something like that,” McKeen said. McKeen’s book is creating a buzz among UF’s Thompson fans, such as Lauren Sachs, a journalism senior, who’s fascinated with the way Thompson broke every journalistic rule.

“Whenever I see or hear or read something of Thompson’s, I immediately see myself in it,” said Sachs, who owns a rescued pet chinchilla named Dr. Gonzo and has taken two classes with McKeen.

In three years, McKeen interviewed about 100 sources and poured over mounds of documents. Although it took some convincing on his part, McKeen landed key interviews with Thompson’s widow, Anita; Deborah Fuller, his assistant for 23 years; Laila Nabulsi, his former girlfriend; and Bob Braudis, Thompson’s best friend.

More than a year later, they came forward after McKeen spoke with Thompson’s longtime friend Monty Chitty.

“Monty teased me about talking on the record for about 18 months, and then he calls me and said, ‘Get a plane ticket. I’m putting you up.’ I don’t know what made him do that, but that sort of helped other people decide I was OK,” said McKeen, who stayed with Chitty in Aspen for 10 days and attended the Hunter S. Thompson Symposium at the Aspen Institute.

Although he worked tirelessly at times to find key sources, other sources found McKeen. For instance, in 2005, Tom Corcoran, an author, journalist and photographer from Lakeland, learned of McKeen’s first book about Thompson and sent him an e-mail. McKeen replied instantly asking Corcoran for an interview.

Corcoran knew Thompson for 28 years and collaborated with him on a series of projects including a never-produced screenplay about marijuana smuggling in the Florida Keys and a never-written Esquire magazine article about powerboat racing. He also worked closely with the journalist in 1981 and 1982 on The Curse of Lono, Thompson’s book about his experiences in Hawaii.

“After Bill and I exchanged a few e-mails, I knew his view of Hunter’s career coincided with mine – I had grown to dislike all the attention given to Hunter’s behavior – and the too-scant praise offered for his brilliant journalism,” said Corcoran, 64. McKeen drove to Lakeland for a face-to-face interview. “I dug out some old memorabilia and yakked until his tape recorder almost caught fire,” Corcoran said.

Since, Corcoran and McKeen have corresponded, leading him to other sources like Jann Wenner, founder of Rolling Stone magazine and former Sen. Gary Hart.

“I gave him a few tips on additional people to contact – friends of Hunter who, like me, had slipped under the radar of all the other biographers,” he said. “We compared notes on a few existing HST ‘legends,’ some true and some built of ‘expanded’ truth. I think I was able to confirm a few stories and debunk a few more.”

Among all of the possible sources for his book, everyone asks McKeen if he talked to Johnny Depp, a friend of Thompson’s who portrayed him in “Fear and Loathing in Las Vegas.”

“Well no, in fact I didn’t even try,” McKeen said. “I feel ashamed, like I should.”

When the biography is released, it will have been five years since McKeen published his last book – a period he calls “an awful long time.”

“It’s like I always say, ‘I don’t like to write. I like to have written,’ ” he said.

“I’ve had such a good time doing this book. What’s funny is when I go back through the copy-edited manuscript, I look back and say, ‘Some of this is really good.’ You don’t really realize what you’re writing when you’re in the frenzy of it.”

June 8, 2008

The Rookies

Link to article: http://www.news.health.ufl.edu/Post/ThePost_May08.pdf (SEE PAGES 12-15)

Published: May 2008, The POST, University of Florida Health Science Center

By Melissa M. Thompson

Impending grads may have mastered the books, but many will learn it takes years to cope with the pressure of professional life when their reputations and patients’ lives are on the line.

Pediatric resident Sarosh Batlivala (photo by Sarah Kiewel)

Pediatric resident Sarosh Batlivala (photo by Sara Kiewel)

Nestled on a foam mattress with blankets draped over her frail, 60-pound frame, Tulip, a 3-week old premature filly, struggled to take each breath. Patches of chocolate-brown fur were missing from her bony flanks while feeding and oxygen tubes jutted from her nostrils. The rhythmic drip … drip … drip of intravenous lines delivered a laundry list of medications throughout her body.

As she lay in the neonatal intensive care unit at the University of Georgia’s Large Animal hospital, battling symptoms from a blood a blood infection, seizures and diarrhea, some veterinary interns caring for the filly saw a heart-wrenching but inevitable death. Amanda House, D.V.M., saw an opportunity to save a young life.

“At one point, she had such severe acidosis hypernatremia (a condition where blood pH is too low and sodium is too high) that she was blind,” says House, a UF assistant professor of equine extension in large animal clinical science in the College of Veterinary Medicine, who was in the senior clinician handling the case in 2005. “Many students, and probably a couple of veterinarians, thought she should be euthanized.”

After using the drug tris-hydroxymethylaminomethane, a product used in human intensive care cases to help improve blood pH without increasing sodium levels in the body, and nearly four months of seesawing in and out of treatment at the hospital, Tulip slowly improved, eventually making a full recovery.

“If I was at the beginning of my career, I may not have been inclined to give the foal a chance,” House says. “Today she’s doing great, galloping around in a beautiful pasture and having a great life.”

Like House, most health-care professionals do not walk off the stage at graduation with Zen-like patience and the ability to solve every medical crisis with the skill and ease of Doogie Howser, M.D. — if it was that easy, the medical industry would be inundated with physicians and there wouldn’t be a nursing shortage. Rather, students and recent grads will learn that it can take years to feel comfortable in their professional skin and that real-life lessons begin beyond the confines of a 2,000-page medical textbook. It’s the sleepless nights spent drafting detailed nursing care plans. The 18-hour marathon shifts in the ER and the beaming smile from a pediatric patient who learns she is cancer-free.

“You get a lot of practice as a senior resident,” says Sarosh “Shawn” Batlivala, a third-year pediatrics resident. “You get to see how everything you do helps kids get better.”

Training Day

Kendyl Atkinson’s living room looks more like a science library than a place to watch “American Idol.” Her coffee table holds pharmacology reference books, while a 5-inch thick text about nursing care management rests on top of a school-bus yellow beanbag across the room. Her laptop has become a permanent extension of her body as she stays up for hours at night writing detailed nursing care plans. This has been life for the past nine months since she started classes as a first-year student in the College of Nursing.

“I thought my first semester of undergrad was hard, but when I went into nursing school it was more difficult than anything I had ever done before,” Atkinson says. “The first shot I ever gave I was shaking because I was so nervous. But the more patients I see, and the more experiences I have, I learn that there are so many areas I might want to go into. Right now, I like the Neuro ICU.”

In 2007, UF awarded nearly 1,700 degrees to students from its six professional colleges, where future nurses, physicians, pharmacists and physical therapists receive intense, hands-on training from day one. As incoming health-care hopefuls begin classes, these students are more likely to look patients in the eye and ask how they’re feeling earlier on in their educational experience than students 30 years ago.

“That’s something I never had,” says Richard Davidson, M.D., M.P.H., chair of the College of Medicine curriculum committee who was a medical student at Vanderbilt University in the late 1960s. “We started to see patients in our second semester of our second year. The way we now introduce clinical medicine on the first day of medical school hopefully helps (students) get a lot of practice from day one.”

First-year students complete three-week preceptorships where they are linked with community-based primary care doctors. In another course, students visit families in their homes along with other health professions students to help foster interdisciplinary work early on. The Harrell Professional Development and Assessment Center also offers an opportunity for students to train, allowing them to interact with
standardized patients, individuals trained to simulate symptoms of ailments or who have stable abnormal physical findings.

Students across the health-education spectrum climb a carefully structured ladder of increasing responsibility. They begin by teetering on the bottom rung, slowly building a solid foundation of knowledge from course plans largely based on objective exams and carefully supervised clinical experiences. In the College of Medicine, third-year students edge closer to the top when they are assigned to monitor two to three patients under the supervision of an attending physician. As a culminating experience in their fourth year, students serve as sub-interns, an experience that Davidson describes as “Internship 101.” Students take on duties similar to first-year interns, ordering nutrition plans, medications, lab tests and other treatments under the supervision of attending physicians.

“I didn’t know what it meant to be an intern until my fourth year,” Batlivala says. “I had two really great senior residents who took me under their wing.”

Davidson says he agrees that most students don’t open their eyes to the reality of the resident lifestyle until their last couple of years of school.

“The first two years of medical school is traditionally similar to college,” he says. “Sometime during their third year they realize they’re really going to have to take care of very sick patients in the middle of the
night, and that it’s really not negotiable. That can be sobering.”

The Contenders

It was late at night in April when most students in Gainesville — with the exception of some procrastinators typing last-minute papers in a caffeinated buzz — were sleeping under a blanket of darkness. But Melanie Wexel, D.D.S., a third-year orthodontics resident, didn’t have that luxury. Under the glow of her office lamp
at the UF College of Dentistry, Wexel was busy compiling her patient review, a written summary of the progress and outcomes of many of the patients she has treated over the past two to three years.

Spending extra time on important projects comes with the territory of being a senior resident, where some days are spent going beyond the call of duty. But when she first moved to Gainesville in 2005 to begin her residency, Wexel dealt with more than adjusting to fluctuating schedules during her transition from dental school to a residency program in an unfamiliar place.

“It took time to get adjusted because I had no family or friends here,” says Wexel, who attended dental school at Virginia Commonwealth University in Richmond, Va. “In the beginning you’re overwhelmed. Orthodontics was like learning a whole new language for me because in my dental school orthodontics was not the primary focus.”

For Wexel, time and experience was the best prescription to become adjusted. As a third-year resident, she said she enjoys how faculty members place their trust in the senior residents’ hands, allowing them to have a large level of independence. Just three years ago, she would treat four to six patients a day. Today, she sees between 10 and 20 patients, while delegating tasks to orthodontic assistants and juggling more than one complex case at a time. Now, she says she is finally seeing the results of patient cases she began two years ago.

“You see (patients) at age 11 and then, all of a sudden, the little boy you’re treating is suddenly taller than you,” says Wexel, who completes her training in May. “It’s a major source of accomplishment in my life
right now.”

Relationships between senior faculty mentors and residents help increase the new professionals’ confidence, allowing them to feel more comfortable as they become more independent. This is at the heart of

many of UF’s professional residency programs, where new physicians, dentists and veterinarians practice medicine alongside pioneers in their fields and specialties.

Pointing at his office wall plastered with more than a dozen framed photographs, Timothy Flynn, M.D., associate dean of graduate medical education for the college’s 650 residents, rattles off the names of young
surgeons he has mentored throughout his 24-year career, never missing a beat. Some have gone on to positions at Brown, University of Tennessee and Vanderbilt, while others have forged careers where they
began, at UF. But they all share one common mentor.

“You develop a strong bond with these people,” Flynn says of his former students. “You’re spending so much time with them, and they’re there because they want to be just like you one day.”

As much as medical students want to end up as successful as their mentors, it takes several years to get there, constantly practicing and building relationships with patients. Six months ago, Batlivala, a pediatrics resident, used a calm, soothing voice to coax a 2-year-old with a cut above his eye to remain still. With the reassurance of his mother, the toddler didn’t cry or struggle as Batlivala moved toward him with a needle to suture his wound, something that probably wouldn’t have gone so smoothly in his days as a medical student.

“Medical school is designed so it gives you th the basis to jump,” Flynn adds. “You don’t learn to be a healer there. That’s the beauty of residency.”

The Champions

So, how long does it really take for a nurse to feel like a nurse and a pharmacist to feel like a pharmacist? The truth is it all depends on the individual.

For Hannah Palmer, Pharm. D., a 2006 College of Pharmacy alumna, the compilation of the lessons she learned at UF hit her in a series of “Ah-ha” moments shared in an e-mail she sent to Paul Doering, M.S., a distinguished service professor in the department of pharmacy practice, in May 2007.

“I was the one who you may remember making a bit of a scene one time in the middle of our literature review class,” writes Palmer, who was completing a pharmacy residency in Charlottesville, Va., last year. “At the time, I could not understand why we took so much time reviewing these studies. I have learned many a thing this year, but if I could pinpoint one thing I have truly perfected it would be my ability to evaluate
literature. I wanted to personally thank you for not reprimanding me at the time of my outrage. I now truly understand the importance of this and often think back to the time of my attack of literature evaluation and wonder how I was so naïve.”

It’s moments of clarity, like Palmer’s, where residents and newly christened professionals realize that when they’re on their own, the white coat or stethoscope are much more than symbols of a profession.

For Flynn, a veteran vascular surgeon, it took about six to eight months after residency to feel like an expert confident in his ability to handle the cases that came his way.

“It can take 10,000 hours to learn to play the violin,” he says. “It might take 10 times as long to learn how to be an expert in your field.”
Remembering Tulip, one of the more intense cases of her postresidency professional career, House
said she feels there will always be cases that surprise doctors, whether they are in their third or 30th year of professional practice.

“I think all of us can relate to a time when we were stressed or panicked about a critically ill case,” she says. “Even as a faculty member, that case taught me a lot. Early on in my career, I wanted to jump to conclusions and know the answer right away. Now I realize how essential it is to keep an open mind and investigate all of the possible diagnoses and options for treatment.”

June 8, 2008

Learning To Throw…Again

throwLink to article:http://news.health.ufl.edu/Post/ThePost_March08.pdf (PAGES 6-7)

Published: March 2008, The POST, University of Florida Health Science Center

By Melissa M. Thompson

David Lowenthal, M.D., Ph.D., stared intently at his nemesis — a dried red bean resting on the table in front of him — while his right hand, the stronger, more dominant hand, was constrained by a thick white mitt equipped with a mesh compartment for his fingers.

After concentrating on the legume for several seconds, he slowly raised his slightly trembling left hand in an effort to pick up the bean between his index finger and thumb, missing once, but then emerging victorious in his second attempt to pluck it off the table and move it three or four inches away from him.

For Lowenthal, an eight-year stroke survivor, there are no small victories, only baby steps in a long journey that has propelled him toward his goal of improving the function of the left side of his body that was affected by the stroke.

“Going through rehabilitation is not for sissies,” joked Lowenthal, a UF professor of medicine, pharmacology and exercise science. “The journey has been arduous but highly rewarding.”

As a participant in the Improving Motor Performance Applying Constraint Therapy study for stroke survivors, Lowenthal, 66, has endured an intense regimen of constraint induced movement therapy, or CIMT, in an
effort to regain the motor skills that will allow him to write or throw a ball with his left hand, his dominant hand before the stroke.

During this form of therapy, participants’ least-affected hands are constrained in mitts for 90 percent of the time they are awake while they use the most-affected hands during repetitive exercises where even the smallest improvements could have a significant effect on their quality of life.

Kathye Light, Ph.D., P.T., a UF associate professor in the department of physical therapy in the College of Public Health and Health Professions, is the principal investigator of the study and principal author of its research grant. She will examine the benefits of CIMT home therapy versus therapy done exclusively in a lab with a trainer.

Subjects are randomly selected for either part of the study. Both sets of participants spend six hours on CIMT exercises each day. The home therapy group spends one hour of this time working with a trainer in the lab and the rest of the time doing the exercises on their own. Patients selected for full lab training perform the same program but do so completely under the guidance of a trainer in the clinic.

Light and her colleagues are interested in discovering if performing exercises at home and spending less time with a trainer can reap the same benefi ts as those who work exclusively with trainers or physical therapists for several hours every week. Another part of the study will evaluate if a second course of CIMT, for survivors who have previously received the treatment, yields added benefit and improved function.

Funding hope

Many stroke survivors are shocked to find out that a two-week CIMT program could cost as much as buying a small car. The time and labor-intensive nature of the therapy account for the expense — about $10,000 to $15,000 for a two-week treatment, Light estimated.

“Insurance will never pay for the expense of sitting for six hours a day for 10 days with a therapist,” said Fran Greenberg, the study’s coordinator. “If this study shows that one hour a day reaps the same benefits, stroke survivors may have a better chance of an insurance company paying for further treatment.”

Prior to I.M.P.A.C.T., Light served as co-principal investigator for Extremity Constraint-Induced Therapy Evaluation, a study that showed CIMT helped stroke survivors improve function years after their strokes occurred.

“In the past, neurologists and other physicians have suggested that patients can make little improvement six months or more after a stroke,” Light said. “We’ve found that’s not true. We’ve worked with people 20 years after their strokes who were able to make great progress and regain function.”

Light began the I.M.P.A.C.T study in 2005 after she was awarded a five-year research grant funded by the National Institutes of Health. The multisite research study at UF, the University of South Carolina and Colorado State University takes the preceding study one step further by examining the parameters surrounding CIMT and will end in June 2010.

No pain, no gain

In this study, the doctor has never been happier to be the patient. Lowenthal knew he would undergo aggressive physical therapy on his left hand and arm — the side most affected by his stroke — while the less affected hand would be placed in a mitt to spur use of the weaker arm to perform activities. Although participants are never pushed to the point of discomfort, the repetition and time in the lab can be mentally and physically taxing.

“Since his stroke, he has become a napper,” said Ronnie, 63, Lowenthal’s wife of nearly 20 years. “There were times when he would train in the lab all day and then go and do some work in the office, which was extremely tiring, but well worth it.”

The lab itself is anything but the stereotypical clinical setting. There are no researchers in sterile-looking white lab coats bustling around the room with clipboards. Rather, participants work with trainers, mostly physical therapy doctoral students, in a room that resembles a place for summer camp activities than a Mecca for scientific research.

Here participants perform exercises, such as Lowenthal’s battle with the bean, designed to improve fine motor skills, flexibility and range of motion while trainers record daily progress.

Jenga, checkers, Scrabble and puzzles are stacked on lab shelves. In the corner, there is a piano and a whiteboard for participants to draw pictures using their most-affected hands. Plastic containers and cans line the countertops where subjects practice making meals and eating lunch. One of the lab’s cabinet cubby holes holds the key to one of Lowenthal’s favorite exercises: the beanbag toss.

He winds up like a seasoned pitcher on a mound, clutching the bubble-gum pink beanbag in his hand and then struggles to maintain balance for a moment — a reminder of why he’s there. Lowenthal points to the ceiling — but it’s a fake-out, and he delivers his best “fastball” to one of his trainers standing across the room.

“This was one of my goals before I came here — to be able to write my name and throw a ball,” he said, in his low, soft-spoken voice, a result of the stroke. “I will leave here having accomplished both goals.”

Back to the basics

Before suffering two strokes within 24 hours in January 2000, Lowenthal was the poster child for healthy living. He was an avid long-distance runner who had completed 15 marathons and exercised at least an hour
every day. He watched what he ate, didn’t smoke or drink. He seemed to do everything right.

In the hours following the stroke, physicians doubted Lowenthal would make it through the night, and if he did, they thought he would never walk again. After nine months of rehab, sweat and determination, Lowenthal escorted his daughter down the aisle at her wedding in September 2000 without the use of a cane or walker.

He applied the same determination during his stay in Light’s lab and said he feels other stroke survivors should take advantage of participating in the study, which is offered at no cost for the subjects.

“I came here two weeks ago with significant defects, and I leave here with a ray of hope,” he said.

Lowenthal’s wife agrees the therapy has helped return a welcomed sense of normalcy to her family’s life.

“People should knock down the door to get in there and get the treatment,” Ronnie said. “It showed me, and it will show other people that you can reconnect the brain to function. If David had to fl y across the country to get this treatment it would have been worth it. Hands down.”